Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Humans are strongly lateralized for manual gestures at both individual and population levels. In contrast, the laterality bias in primates is less strong, leading some to suggest that lateralization evolved after the Pan and Homo lineages diverged. However, laterality in humans is also context-dependent, suggesting that observed differences in lateralization between primates and humans may be related to external factors such as the complexity of the social environment. Here we address this question in wild chimpanzees and examine the extent to (...) which the laterality of manual gestures is associated with social complexity. Right-handed gestures were more strongly associated with goal-directed communication such as repair through elaboration in response to communication failure than left-handed gestures. Right-handed gestures occurred in evolutionarily urgent contexts such as in interactions with central individuals in the network, including grooming reciprocity and mating, whereas left-handed gestures occurred in less-urgent contexts, such as travel and play. Right-handed gestures occurred in smaller parties and in the absence of social competition relative to left-handed gestures. Right-handed gestures increased the rate of activities indicating high physiological arousal in the recipient, whereas left-handed gestures reduced it. This shows that right- and left-handed gestures differ in cognitive and social complexity, with right-handed gestures facilitating more complex interactions in simpler social settings, whereas left-handed gestures facilitate more rewarding interactions in complex social settings. Differences in laterality between other primates and humans are likely to be driven by differences in the complexity of both the cognitive skills underpinning social interactions and the social environment. (shrink)

Substantial research demonstrates that ethical leaders improve a broad range of outcomes for their employees, but considerably less attention has been devoted to the performance and success of the leaders themselves. The present study explores the extent to which being ethical relates to leaders’ performance and promotability. We address this question by examining ethical leadership from the two ethical perspectives most common in Western traditions—i.e., the “right” and the “good”—and whether one might be more closely associated than the other with (...) performance and promotability evaluations. Results from 117 employee-supervisor-manager triads show that supervisors with a deontological outlook are more likely to be seen as ethical leaders and that utilitarian leaders are more likely to earn higher performance evaluations. We discuss the implications of these findings for research on ethical leadership. (shrink)

Many philosophical naturalists eschew analysis in favor of discovering metaphysical truths from the a posteriori, contending that analysis does not lead to philosophical insight. A countercurrent to this approach seeks to reconcile a certain account of conceptual analysis with philosophical naturalism; prominent and influential proponents of this methodology include the late David Lewis, Frank Jackson, Michael Smith, Philip Pettit, and David Armstrong. Naturalistic analysis is a tool for locating in the scientifically given world objects and properties we quantify (...) over in everyday discourse. This collection gathers work from a range of prominent philosophers who are working within this tradition, offering important new work as well as critical evaluations of the methodology. Its centerpiece is an important posthumous paper by David Lewis, "Ramseyan Humility," published here for the first time. The contributors first address issues of philosophy of mind, semantics, and the new methodology's a priori character, then turn to matters of metaphysics, and finally consider problems regarding normativity. Conceptual Analysis and Philosophical Naturalism is one of the first efforts to apply this approach to such a wide range of philosophical issues. _Contributors: _David Braddon-Mitchell, Mark Colyvan, Frank Jackson, Justine Kingsbury, Fred Kroon, David Lewis, Dustin Locke, Kelby Mason, Jonathan McKeown-Green, Peter Menzies, Robert Nola, Daniel Nolan, Philip Pettit, Huw Price, Denis Robinson, Steve Stich, Daniel Stoljar The hardcover edition does not include a dust jacket. (shrink)

This book review outlines and comments on the ten sections of Robert Allinson’s edited collection, Understanding the Chinese Mind: The Philosophical Roots. It begins with John E. Smith, whose essay presents three types of intercultural scholarly occurrences: parallels and agreements, divergences, and conflict. Next is Robert Neville, who discusses common ontological and cosmological themes in Confucianism, Daoism, and Sinicized Buddhism. General themes are then tied to Plato and the mystical side of Western monotheistic religions. In the following essay, Chad Hansen (...) discusses his interpretation of the Chinese theory of language, suggesting that the prescriptive and socializing nature of the Chinese language make for a radically different conceptions of language and mind from Western theories (except functionalist theories), one in which concerns for truth are secondary. In response to Hansen, Christoph Harbsmeier draws on Chinese classical philosophy to argue that a concern for truth is central in the Chinese canon. The reviewer then comments on the limitations of Harbsmeier’s critique, which adopts Tarski’s ‘T schema’ of truth to assess notions of truth in Chinese classical philosophy. Continuing with the essays, Chung-ying Cheng compares Chinese and Western metaphysics on the Parmenidean problem of change. Drawing mainly from Xunzi, Antonio Cua sets up a dialogue between Confucianism and Anglo-American moral philosophy on the function and justification of ritual code. Kuang-ming Wu compares and contrasts prominent Chinese and Western approaches to the apprehension of beauty in the arts, the former being heavily analytical and prone to universal generalizations and the latter being more adumbrative and contextualized. The reviewer then comments on Wu’s apparent omission of the difference between a Western experience of beauty and Western philosophizing about the experience of beauty. The last essay, Lao Sze-kwang suggests that the difference between the practical, “orientative” direction of Chinese philosophy which aims at effecting change in the self or the world and the highly theoretical slant of Western philosophy as an absolute difference between the two canons, a difference which the reviewer welcomes but at the same time pulls back from any claims of absoluteness. Finally, the book review turns to Allinson’s introduction, which reflects on the multiplicity of perspectives in both Western and Chinese mind and, like Sze-kwang, draws attention to the higher degree of emphasis that Chinese philosophy places on practice, explaining the difference in part in terms of the propensity of Chinese philosophers to envision humanity as in or capable of regaining fundamental harmony with the cosmos. The reviewer concludes with suggestions for further dialogues. (shrink)

themes among the essays resurface and resonate. Though our request for essays was broad and open-ended, we found that topics such as seeing, authenticity, interpretation, wholeness, care, and dwelling ran as undercur rents throughout. Our major hope is that each essay plays a part in revealing a larger whole of meaning which says much about a more humane relation ship with places, environments and the earth as our home. Part I. Beginnings and directions At the start, we recognize the tremendous (...) debt this volume owes to philosopher Martin Heidegger (1890-1976), whose ontological excavations into the nature of human existence and meaning provide the philosophical foundations for many of the essays, particularly those in Part I of the volume. Above all else, Heidegger was regarded by his students and colleagues as a master teacher. He not only thought deeply but was also able to show others how to think and to question. Since he, perhaps more than anyone else in this century, provides the instruction for dOing a phenomenology and hermeneutic of humanity's existential situation, he is seminal for phenomenological and hermeneutical research in the environmental disci plines. He presents in his writings what conventional scholarly work, especially the scientific approach, lacks; he helps us to evoke and under stand things through a method that allows them to come forth as they are; he provides a new way to speak about and care for our human nature and environment. (shrink)

The issue of social welfare and individual responsibility has become a topic of international public debate in recent years as politicians around the world now question the legitimacy of state-funded welfare systems. David Schmidtz and Robert Goodin debate the ethical merits of individual versus collective responsibility for welfare. David Schmidtz argues that social welfare policy should prepare people for responsible adulthood rather than try to make that unnecessary. Robert Goodin argues against the individualization of welfare policy and expounds (...) the virtues of collective responsibility. (shrink)

The moral potential of works of art, for good or ill, has been recognised from philosophical antiquity: on the assumption that the moral effects of art are invariably negative, Plato advised the exclusion of artists from any rationally ordered state. Arguably, however, the problem of the moral status of art has become yet more acute in contexts of post-Romantic and other modern artistic exploration of moral ambiguity, and even of some apparent contemporary celebration of the immoral and amoral. Indeed, some (...) tension between commitment to liberal-democratic openness and freedom, on the one hand, and fear about the potential literary and artistic corruption of the young, on the other, is evident in latter-day moralistic trends in children’s literature. However, in the light of some basic exploration of conceptual relationships between the artistic, the aesthetic and the moral, this paper argues that such moralising trends in particular and arguments for artistic censorship in general are mostly wrongheaded and unsustainable. (shrink)

Volume 20, Issue 5, June 2020, Page 40-42.

The Hybrid View endorses utilitarianism about animals and rejects utilitarianism about humans. This view has received relatively little sustained attention in the philosophical literature. Yet, as we show, the Hybrid View underlies many widely held beliefs about zoos, pet ownership, scientific research on animal and human subjects, and agriculture. We develop the Hybrid View in rigorous detail and extract several of its main commitments. Then we examine the Hybrid View in relation to the view that human use of animals constitutes (...) a special relationship. We show that it is intuitively plausible that our use of animals alters our moral obligations to animals. That idea is widely believed to be incompatible with the sort of utilitarian approach in animal ethics that is prescribed by the Hybrid View. To overturn that conventional wisdom, we develop two different principles concerning the moral significance of human use of animals, which we call the Partiality Principle and the Strengthening Principle. We show that the Partiality Principle is consistent with several key commitments of the Hybrid View. And, strikingly, we show that the Strengthening Principle is fully consistent with all of the main commitments of the Hybrid View. Thus we establish the surprising result that utilitarians about animals can coherently offer a robust and intuitively appealing account of the moral significance of animal use. (shrink)

The distinctive feature of a hybrid view (such as Nozick’s “utilitarianism for animals, Kantianism for people”) is that it divides moral patients into two classes: call them dersons and uersons. Dersons have a deontological kind of moral status: they have moral rights against certain kinds of optimific harms. Uersons, by contrast, have a utilitarian kind of moral status: their interests are morally important (in proportion to the magnitude of those interests), but uersons do not have deontological moral rights or any (...) other kinds of deontological protections. In this paper, we discuss and critically evaluate three ways of supporting a hybrid view: a case-based argument; an autonomy-based rationale; and a rationale based in a capacity for what we call deep commitments. Finally, we discuss a way in which considerations about the moral significance of relationships might support an approximation of a hybrid view. (shrink)

In this paper, we introduce a novel difficulty for teleosemantics, viz., its inability to account for what we call unexploited content—content a representation has, but which the system that harbors it is currently unable to exploit. In section two, we give a characterization of teleosemantics. Since our critique does not depend on any special details that distinguish the variations in the literature, the characterization is broad, brief and abstract. In section three, we explain what we mean by unexploited content, and (...) argue that any theory of content adequate to ground representationalist theories in cognitive science must allow for it.1 In section four, we show that teleosemantic theories of the sort we identify in section two cannot accommodate unexploited content, and are therefore unacceptable if intended as attempts to ground representationalist cognitive science. Finally, in section five, we speculate that the existence and importance of unexploited content has likely been obscured by a failure to distinguish representation from indication, and by a tendency to think of representation as reference. (shrink)

Background: Current practice relies on patient-designated and next-of-kin surrogates, in consultation with clinicians, to make treatment decisions for patients who lose the ability to make their own decisions. Yet there is a paucity of data on whether this approach is consistent with patients' preferences regarding who they want to make treatment decisions for them in the event of decisional incapacity. Methods: Self-administered survey of patients at a tertiary care center. Results: Overall, 1169 respondents completed the survey (response rate = 59.8%). (...) Of the 229 respondents who had previously designated a surrogate, 78.2% wanted their surrogate to make treatment decisions in the event of decisional incapacity, whereas 21.8% wanted their doctors to make treatment decisions. Of the 822 respondents who had not designated a surrogate, 66.1% wanted their family to make treatment decisions, whereas 33.9% wanted their doctors to make treatment decisions. The most common explanation provided for why respondents wanted their surrogate or family to make treatment decisions for them in the event of decisional incapacity was the belief that loved ones knew the patient's treatment preferences. Conclusions: Contrary to current practice, 33.9% of respondents who had not designated a surrogate and 21.8% of those who had designated a surrogate indicated that they wanted their doctors to make treatment decisions for them in the event of decisional incapacity. Moreover, many of those who wanted their surrogates or family members to make treatment decisions explained this preference by citing a belief that loved ones knew the patient's treatment preferences. This belief is undermined by prior research that suggests that surrogates and family members frequently are unable to predict which treatments their charges would want. Future research should assess these two concerns with current practice and, where necessary, identify approaches to address them. (shrink)

Social and regional inequality remained of secondary importance in the 2017 House of Representatives election, especially in comparison to national security and constitutional reform. Still, the election victory of the coalition between the Liberal Democratic Party (LDP) and Kōmeitō was also due to its ability to shape the debate concerning Japan’s political-economic model of growth and inequality. Abenomics and regional revitalization were the dominating policies, which opposition parties criticized without having a real counter-model. A more detailed analysis shows, however, that (...) Abenomics has not yet fulfilled its promise of shared growth, and that the governing coalition’s discursive control over the political-economic agenda has significantly weakened. This creates opportunities for opposition parties in the future. (shrink)

In this 2001 volume a group of leading philosophers address some of the basic conceptual, methodological and ethical issues raised by genetic research into criminal behavior. The essays explore the complexities of tracing any genetic influence on criminal, violent or antisocial behavior; the varieties of interpretations to which evidence of such influences is subject; and the relevance of such influences to the moral and legal appraisal of criminal conduct. The distinctive features of this collection are: first, that it advances public (...) discussion while clarifying the debate about genetic research and criminal behavior; second, that it explains scientific controversies about behavioral genetics in lucid, non-technical terms; third, that it demonstrates how the possible findings on genetics and crime bear on fundamental issues of moral and criminal responsibility. The volume will be of particular value to philosophers concerned with applied ethics, behavioral geneticists, psychologists, legal theorists, and criminologists. (shrink)

ABSTRACT The demand for basic research ethics training has grown considerably in the past few years. Research and education organizations face the challenge of providing this training with limited resources and training tools available. To meet this need, Family Health International (FHI), a U.S.‐based international research organization, recently developed a Research Ethics Training Curriculum (RETC). It was designed as a practical, user‐friendly tool that provides basic, up‐to‐date, standardized training on the ethics of human research. The curriculum can easily be adapted (...) to different audiences and training requirements. The RETC was reviewed by a group of international experts and field tested in five countries. It is available in English, French, and Spanish as a three‐ring binder and CD‐ROM, as well as on the Web. It may be used as either an interactive self‐study program or for group training. (shrink)

Sleep and mental health are important aspects of human health that work concurrently. However, sleep and mental health disorders are often overlooked and undiagnosed in sport due to the negative stigma associated with them. Evidence suggests that athletes are disproportionately affected by mental health issues and sleep problems. Internal and external pressures contribute to psychological distress. Variable competition times, travel and stress are detrimental to sleep quality. Retirement from sport can deteriorate sleep and psychological wellbeing, particularly for those who retired (...) involuntarily and identify strongly with their athletic role. When untreated, these issues can manifest into a range of clinical disorders. This is concerning, not only for compromised athletic performance, but for general health and wellbeing beyond sport. Previous research has focussed on sleep and health independently among currently competing, or former, athletes. To date, no research has comprehensively assessed and compared sleep complaints and mental health issues between these two cohorts. Moreover, research has failed to obtain data across a variety of different competition levels, sports, and genders, leaving the current scope of the literature narrow. Comorbid conditions, ex-college athletes, and mental health has been the focus of existing literature post-retirement. Future research would benefit from employing both quantitative and qualitative methodologies to comprehensively assess the prevalence and severity of sleep and mental health disorders across current and retired athletes. Research outcomes would inform education strategies, safeguarding athletes from these issues by reducing negative stigmas associated with help-seeking in sport and ultimately increase self-guided treatment. (shrink)

This article discusses a complexity-informed review and evaluation project. Complexity-informed methods and techniques are used to fashion understanding of the relationships and processes implicated between the service agencies constituting the Youth Accommodation Interagency - Nepean (YAIN) and their Resource Worker, the influence of these relationships and processes on the achievement of desired and required goals, and the potential for replication of these relationships and processes elsewhere. The article concludes with critical reflection regarding what was learnt from utilizing complexity in this (...) qualitative inquiry. (shrink)